NCT02520830

Effects of Blueberry-polyphenols on Endothelial Function, Absorption and Metabolism

Sustained Effects of Blueberry Polyphenols on Vascular Function in Healthy Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Heinrich-Heine University, Duesseldorf · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Diets rich in fruits and vegetables have been linked to favorable cardiovascular outcomes in epidemiological studies. Dietary intervention studies with certain micronutrients have shown promising effects on surrogate parameters of vascular risk including blood pressure, endothelial function and cholesterol levels. Wild blueberries have gained attention due to their high content of phytochemicals and particularly anthocyanins. Whether wild blueberries can improve vascular function and health when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of wild blueberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Blueberry Group	22 grams freeze-dried blueberry powder per day. Sustained intake (2x 11 grams daily over 1 month) of a drink consisting on freeze-dried wild blueberry powder dissolved in water
DIETARY_SUPPLEMENT	Placebo Group	Sustained intake (2x 11 grams daily over 1 month) of a drink consisting in placebo powder dissolved in water

Timeline

• Start date: 2014-03-01
• Primary completion: 2015-09-01
• Completion: 2015-09-01
• First posted: 2015-08-13
• Last updated: 2015-11-03

Locations

1 site across 1 country: Germany