NCT02518789

Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus

Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus During General Anesthesia Induction Period

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 132 (estimated)
• Sponsor: Tang-Du Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

By observing the difference of plasma homovanillic acid concentrations and brain electrical consciousness monitoring Narcotrend index, study the possible mechanism of influencing Etomidate induced myoclonus with Dexmedetomidine pretreatment during general anesthesia induction period.

Conditions

• Myoclonus

Interventions

Type	Name	Description
DRUG	Low-dose Dexmedetomidine	Pretreatment：Intravenous injection dexmedetomidine 0.5 µg/kg ，completed within 15 minutes.
DRUG	High-dose dexmedetomidine	Pretreatment：Intravenous injection dexmedetomidine 1 µg/kg ，completed within 15 minutes.
DRUG	normal saline	Pretreatment：Intravenous injection normal saline equal quantity，completed within 15 minutes.
DRUG	Etomidate	After 90 seconds of Pretreatment，intravenous infusion of etomidate fat emulsion 0.3mg/kg. -Does not offer any other drugs within 5 min after completion of etomidate.
DRUG	midazolam，fentanyl，rocuronium	Anesthesia induction：Intravenous injection midazolam 0.03 \~ 0.05 mg/kg, fentanyl 5 \~ 8 g/kg, rocuronium 0.6 mg/kg
DRUG	propofol，remifentanil，cis atracurium	Anesthesia maintenance：Intravenous infusion of propofol 4 \~ 6 mg/kg/h, remifentanil 0.1 \~ 0.3 μg/kg/min, intermittent intravenous injection of cis atracurium 0.05 \~ 0.1mg/kg

Timeline

• Start date: 2015-09-01
• Primary completion: 2016-08-01
• Completion: 2016-09-01
• First posted: 2015-08-10
• Last updated: 2015-08-10