NCT02517190

Effects of Repeated Short-term Microgravity During Parabolic Flight Conditions on Neuro-endocrine, Immune and Metabolic Changes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

From previous parabolic flight campaigns completed by our research group investigators gathered data showing important changes in neuro-endocrine and also immunological changes. This experiment now will complete the data set-up obtained during the MARS500 study on how these respective individuals will re-act to highly physically and emotionally challenging situations during a parabolic flight. This add-on experiment to MARS500 will enable answering to the following questions i) if the stress response systems - when compared for two conditions but in the same individuals - do react uniformly and ii) if those subjects prone to have adequate stress response pattern will show gradually less immune modulation effects. The understanding of the complex interactions of stress and immunity under chronic and acute stress conditions might help to enable adequate health and immune monitoring and might as well suggest suitable countermeasures for the prevention of the unwanted immunological effects during long-term confinement and space missions.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Parabolic flight
OTHER	neuro-endocrine measurements	psychic stress tests, stress hormones: prolactin, cortisol, endo-cannabinoids
OTHER	immunological measurements	blood cell counts, B2 integrins, cytokines, C-reactive protein
OTHER	cellular energy metabolism measurements	purines, lactate

Timeline

• Start date: 2012-05-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2015-08-06
• Last updated: 2015-08-06

Locations

1 site across 1 country: France