NCT02516787

Coherence Between Brain Cortical Function and Neurocognitive Performance During Changed Gravity Conditions

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Alongside a well-known physiological deconditioning, such as a decrease in muscle mass or bone demineralization, extended stays in weightlessness also cause cognitive dysfunction. However, the studies on this subject during space missions short or long term could not determine how these cognitive dysfunction resulted from a direct effect of weightlessness or a stress-related effect. Analysis of electro-encephalography (EEG) using a standardized mapping method is used to study the changes of operation of the cerebral cortex as the near infrared spectroscopy (NIRS) is a reflection of changes in the cerebral hemodynamics. Their combined use is a relatively simple and economical method for studying brain changes in an environment where the normal brain imaging techniques can not be used. The main objective of this experiment is to evaluate the alterations in brain cortical activity and brain oxygenation level induced by micro- and hypergravity conditions.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Parabolic flight
OTHER	EEG measurement	Electro cortical power in alpha frequency ranges (EEG-LORETA)
OTHER	NIRS measurements	Brain tissue oxygenation ( oxy- or deoxygenated hemoglobin values) - NIRS

Timeline

• Start date: 2010-11-01
• Primary completion: 2013-11-01
• First posted: 2015-08-06
• Last updated: 2015-08-06

Locations

1 site across 1 country: France