Trials / Terminated
TerminatedNCT02513589
Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke
- Status
- Terminated
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 3 (actual)
- Sponsor
- University Hospital, Bordeaux · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (\<15 days) with carotid stenosis\> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with PBR06 18F, a tracer for Translocator protein (TPSO).
Detailed description
More than one third of cerebral ischemic events are related to an atheromatous plaque. Inflammation, through a key player, the macrophage, is associated with increased metabolic activity of atherosclerotic plaque and its possible rupture. Inflammation within the plate is thus a marker of instability. These data underscore the importance of a prospective evaluation of inflammation with specific imaging with PET tracers inflammation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | 18F-PBR06 | Positron Emission Tomography / Computed Tomography (PET-CT) using 18F-PBR06 |
Timeline
- Start date
- 2017-09-18
- Primary completion
- 2018-07-04
- Completion
- 2018-07-04
- First posted
- 2015-07-31
- Last updated
- 2018-11-23
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02513589. Inclusion in this directory is not an endorsement.