NCT02510612

Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism

Perioperative Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Shaanxi Provincial People's Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Dexmedetomidine's Sedative Effect on Diabetic Patient

Detailed description

Dexmedetomidine is a high selective α2 agonist,its sedative and analgesia feature is acclaimed. The pathogenesis of type 2 diabetes mellitus is associated with α2 excessive adrenaline receptors expression. This study is to evaluate whether the use of dexmedetomidine is helpful to Diabetic Patient through its antisympathetic effect

Conditions

• Diabetes

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Dexmedetomidine(D) group, patient will be given dexmedetomidine 1μg/Kg for 10 minutes In anesthesia maintenance, D group will be given dexmedetomidine 0.4μg/Kg.h until 40 minutes before the end of surgery
DRUG	placebo	During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Placebo(P) group, patient will be given placebo for 10 minutes In anesthesia maintenance, D group will be given placebo until 40 minutes before the end of surgery

Timeline

• Start date: 2015-08-01
• Primary completion: 2016-08-01
• Completion: 2016-12-01
• First posted: 2015-07-29
• Last updated: 2015-07-29