NCT02504528

Bronchial Allergen Provocation Tests in Asthmatics in Guangzhou

Bronchial Provocation Tests With House Dust Mite in Allergic Asthma in Guangzhou

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Guangzhou Institute of Respiratory Disease · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to establish the methodology of bronchial provocation tests with house dust mites in China, and to evaluate its safety and effects on upper and lower airways inflammation.

Detailed description

After screening,each participant undergo baseline lung function test,airway inflammation evaluation (blood and sputum eosinophils count,interleukin-13 (IL-13),FeNO)and airway responsiveness tests(methacholine bronchial provocation,nasal histamine provocation). On the second day,the participant undergo bronchial house dust mites challenge tests. On the third day,the participant undergo the lung function test,airway inflammation evaluation (blood and sputum eosinophils count,IL-13,FeNO)and airway responsiveness tests(methacholine bronchial provocation,nasal histamine provocation).

Conditions

• Allergic Asthma

Interventions

Type	Name	Description
OTHER	house dust mites	house dust mites(two-fold increasing concentration of house dust mite (HDM) extract, dilutions prepared starting from 1:8, 1:16, 1:32, 1:64, 1:128, 1: 256, 1:512, 1:1024,……)

Timeline

• Start date: 2015-07-01
• Primary completion: 2017-07-01
• Completion: 2018-02-01
• First posted: 2015-07-22
• Last updated: 2018-02-19

Locations

1 site across 1 country: China