NCT02503800

The Significance of Blood-tryptase and c-Kit Mutation in Insect Venom Immunotherapy

The Significance of Blood-tryptase Levels and c-Kit Mutation in the Evaluation of Prognosis and Adverse Reactions in Subjects Undergoing Venom Immunotherapy for Insect Allergy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 159 (actual)
• Sponsor: Meir Medical Center · Academic / Other
• Sex: All
• Age: 4 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The investigators wish to evaluate the association between tryptase values as well as c-Kit mutation and adverse effects in the course of immunotherapy. The investigators also intend to assess the effect of immunotherapy on tryptase levels.

Detailed description

According to the presently available reports there is an association between systemic allergic responses to hymenoptera venom and elevated tryptase levels or c-Kit mutation. The presence of these findings may imply the existence of mast cell activation syndrome or mastocytosis. Therefore, baseline tryptase evaluation has become standard evaluation in patients with systemic responses. Meir Medical Center is the only hospital in Israel in which tryptase can be measured. Consequently, the Meir Clinic has accumulated considerable data with regards to tryptase levels in subjects with allergy to hymenoptera venom. The investigators wish to evaluate the association between tryptase values as well as c-Kit mutation and adverse effects in the course of immunotherapy. The investigators also intend to assess the effect of immunotherapy on tryptase levels.

Conditions

• Hypersensitivity, Immediate
• Insect Bites and Stings
• Mastocytosis

Timeline

• Start date: 2015-08-01
• Primary completion: 2019-02-15
• Completion: 2019-02-15
• First posted: 2015-07-21
• Last updated: 2019-08-20

Locations

1 site across 1 country: Israel