NCT02502825

Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers

Comparison of 2-min Tidal Breathing Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Guangzhou Institute of Respiratory Disease · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare the diagnostic validity (sensitivity and specificity) and evaluate the safety of 2-min Tidal Breathing methacholine bronchial provocation tests with the Wright and Devilbiss646 nebulizers in asthmatic in Guangzhou.

Detailed description

After screening,each asthmatic patient will visit the investigators' center 4 times. During the first week, the patient will be randomised to undergo methacholine bronchial challenge with Wright or Devilbiss 646 nebulizer on two separate days, which are at least 24 hours but not more than 7 days apart.The above procedure will be repeated for each patient in one month. But the nebulizer will be selected in a reverse order.Provocative concentration induced a 20% decrease in forced expiratory volume in one second (PC20) will be calculated for each test. Record all the adverse events during the tests.

Conditions

• Asthma

Interventions

Type	Name	Description
OTHER	methacholine	methacholine (0.03,0.06,0.125,0.5,1.0,2.0,4.0,8.0,16.0 mg/ml),Canada
DEVICE	Wright Nebulizer	nebulized for 2 minutes with an output of 0.13ml/min
DEVICE	Devilbiss646 Nebulizer	nebulized for 2 minutes with an output of 0.13ml/min

Timeline

• Start date: 2015-07-01
• Primary completion: 2016-07-01
• Completion: 2016-12-01
• First posted: 2015-07-20
• Last updated: 2018-02-19

Locations

1 site across 1 country: China