NCT02502032

Effects of Cisatracurium on Sccinylcholine-induced Fasciculations

Effects of Pretreatment With Different Doses of Cisatracurium on Succinylcholine-induced Fasciculations

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 87 (actual)
• Sponsor: Zhuan Zhang · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.

Detailed description

Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.

Conditions

• Fasciculations

Interventions

Type	Name	Description
DRUG	Cisatracurium	Different groups received different pretreatments of cisatracurium.

Timeline

• Start date: 2015-07-01
• Primary completion: 2015-10-01
• Completion: 2015-10-01
• First posted: 2015-07-17
• Last updated: 2015-10-12