NCT02498938

The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders

Evaluation of SERPINA1 Gene Polymorphisms in COPD as a Risk Factor for Periodontitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.

Detailed description

periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs. SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums. Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.

Conditions

• Pulmonary Disease, Chronic Obstructive
• Generalized Chronic Periodontitis

Interventions

Type	Name	Description
GENETIC	SERPINA1 gene	2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2015-07-15
• Last updated: 2016-08-29

Locations

1 site across 1 country: India