NCT02498431

Serum Irisin in Myocardial Infraction and Following Percutaneous Coronary Intevention

Serum Irisin Levels in Myocardial Infraction and Following Percutaneous Coronary Intevention

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (actual)
• Sponsor: 424 General Military Hospital · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The investigators aim to evaluate circulating irisin levels alterations in patients with acute myocardial infraction and in patients with coronary artery disease subjected to percutaneous coronary intervention.

Detailed description

Irisin is a newly discovered myokine induced in exercise. There is evidence that cardiac muscle produces more irisin than skeletal muscle in response to exercise. Furthermore, irisin has been associated with isoproterenol-induced myocardial infarction (MI) in rats while it has been reported to decrease after acute myocardial infarction in humans. The investigators aim 1) to investigate circulating irisin levels in patients at the time of acute myocardial infarction and after reprefusion \[primary percutaneous coronary intervention (PCI)\] 2) to compare irisin' s diagnostic and prognostic value and specificity value in myocardial infarction with known markers of cardiac injury such as creatine kinase-MB isoenzyme (CK-MB) and troponin 3) to evaluate irisin as an early necrosis biomarker 4) To evaluate irisin's sensitivity as a biomarker to detect minor myocardial necrosis after elective percutaneous coronary intervention

Conditions

• Myocardial Infarction
• Coronary Artery Disease

Interventions

Type	Name	Description
PROCEDURE	percutaneous coronary intervention	a non-surgical procedure used to treat the stenotic (narrowed) coronary arteries of the heart found in coronary heart disease
PROCEDURE	coronary angiography	is a procedure performed along with cardiac catheterization that uses X-ray imaging to see your heart's blood vessels
DEVICE	Stent, Medronic Resolute Integrity	A stent is placed in an artery as part of a procedure called percutaneous coronary intervention (PCI) to restore blood flow through narrow or blocked arteries. A stent helps support the inner wall of the artery in the months or years after PCI.

Timeline

• Start date: 2015-06-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2015-07-15
• Last updated: 2017-01-18

Locations

1 site across 1 country: Greece