NCT02498236

Target Engagement for Oxytocin: Dose Ranging Study

Target Engagement for Oxytocin: Response to 8 Doses

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study will evaluate the effect of 8 doses of intranasal oxytocin or placebo on two proposed measures of target engagement in brain. The targets are (1) the suppression of a particular wave form (mu) on the electroencephalogram (EEG) while subjects observe a socially relevant form of motion and (2) pupil dilation will subjects identify faces showing different emotions.

Detailed description

Subjects with schizophrenia spectrum disorders will be randomly assigned to one of 8 doses of oxytocin. After screening and informed consent subjects will receive either their assigned dose or a placebo. Thirty minutes following the drug administration patients will be evaluated on the EEG and pupillometry tasks followed by two tests that evaluate social salience. One week later subjects will have a second challenge in the alternative (drug or placebo) condition.

Conditions

• Schizophrenia Spectrum

Interventions

Type	Name	Description
DRUG	Intranasal Oxytocin

Timeline

• Start date: 2015-09-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2015-07-15
• Last updated: 2019-01-31
• Results posted: 2019-01-31