NCT02493959

Degradation of the Anorexic Hormone Peptide YY

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.

Conditions

• Healthy

Interventions

Type	Name	Description
BIOLOGICAL	PYY1-36 infusion	Infusion of 1.6 pmol/kg/min PYY1-36 for 2 hrs.
BIOLOGICAL	PYY1-36 + sitagliptin	Infusion of 1.6 pmol/kg/min PYY1-36 for 2 hrs. Two doses of 100 mg sitagliptin are administered 10 and 1 hour before start of infusion, respectively.
BIOLOGICAL	PYY3-36 infusion	0.8 pmol/kg/min infusion of PYY3-36.
BIOLOGICAL	placebo	Infusion of saline for 2 hrs.

Timeline

• Start date: 2014-05-01
• Primary completion: 2015-07-01
• Completion: 2015-07-01
• First posted: 2015-07-10
• Last updated: 2015-07-10

Locations

1 site across 1 country: Denmark