NCT02492802

Effect of Inflammation on Pharmacokinetics of Posaconazole

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 64 (actual)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Posaconazole plasma concentration and inflammatory markers will be determined in all samples available from routine analysis.

Detailed description

A prospective observational study will be performed at the University Medical Center Groningen, the Netherlands using longitudinal data collection. The design of the study will be that patients starting on posaconazole treatment will be evaluated. After informed consent is obtained medical data will be collected from the medical chart. Posaconazole plasma concentration (trough levels) and inflammatory markers (e.g. C-reactive protein) will be determined in all samples available from routine analysis (often daily). This will result in a detailed data set capturing day to day variations in inflammation and drug concentrations.

Conditions

• Mycoses

Interventions

Type	Name	Description
DRUG	posaconazole	collection plasma samples for measuring posaconazole drug concentration

Timeline

• Start date: 2015-08-13
• Primary completion: 2017-06-01
• Completion: 2017-08-01
• First posted: 2015-07-09
• Last updated: 2019-08-06
• Results posted: 2019-06-07

Locations

1 site across 1 country: Netherlands