NCT02492074

Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study

Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids on the Endocannabinoid System and Brain Function

• Status: Withdrawn
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Central Institute of Mental Health, Mannheim · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The study evaluates the gene-environment interaction of the COMT-genotype on the effects of the phytocannabinoids delta-9-tetrahydrocannabinol, cannabidiol or a combination of both on induction of psychotic symptoms, endocannabinoid levels in human body fluids, neuronal processing, and neural oscillations. In addition the effects of the phytocannabinoids on lipid levels in serum and cerebrospinal fluid, cognition, neuronal processing assessed by fMRI as well as D2-receptor availability assessed by \[18F\] desmethoxyfallypride.

Conditions

• Healthy Volunteers
• Modeling Psychosis

Interventions

Type	Name	Description
DRUG	Delta-9-tetrahydrocannabinol	oral administration of delta-9-tetrahydrocannabinol
DRUG	Cannabidiol	oral administration of cannabidiol
DRUG	Placebo	oral administration of placebo

Timeline

• Start date: 2024-12-01
• Primary completion: 2025-04-01
• Completion: 2025-05-01
• First posted: 2015-07-08
• Last updated: 2025-03-13

Locations

1 site across 1 country: Germany