Trials / Completed
CompletedNCT02491151
Variability of Fluconazole Concentration in Critically Ill Patients
Fluconazole Exposure in Critically Ill Patients and the Value of Therapeutic Drug Monitoring
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (actual)
- Sponsor
- University Medical Center Groningen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Fluconazole is the first-line agent in the treatment of invasive candidiasis. Studies showed inappropriate drug exposure causes high mortality in critically ill patients. Under-dosing and ineffective fluconazole trough serum concentrations were found in a recent retrospective study. Variability in fluconazole exposure can be easily measured with therapeutic drug monitoring. For patient groups who are at risk for drug underexposure, therapeutic drug monitoring can be valuable regards decreasing mortality.
Conditions
Timeline
- Start date
- 2014-10-01
- Primary completion
- 2016-12-01
- Completion
- 2016-12-01
- First posted
- 2015-07-07
- Last updated
- 2017-05-03
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT02491151. Inclusion in this directory is not an endorsement.