NCT02489240

Efficacy Study of Vitamin D to Treat Contrast-induced Nephropathy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 306 (estimated)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The investigators planned to research the effect of vitamin D supplementation on the incidence of contrast-induced nephropathy in patients undergoing coronary angiography.

Detailed description

Vitamin D is primarily generated in the skin, in response to direct absorption of ultraviolet B radiation. Vitamin D can also be obtained through fortified foods and oral supplements. Contrast-induced nephropathy (CIN) is a generally reversible form of acute kidney injury that occurs mostly within 2-3 days of exposure to contrast medium (CM). The estimated incidence of CIN ranges from 2%-50%, and coronary angiography (CAG) or percutaneous coronary intervention (PCI), or both, are associated with CIN in about half of cases. Recently low vitamin D status has been shown to be associated with increased risk of CIN. However, its effects on CIN patients remain unclear. The investigators planned to determine the efficacy of vitamin D on the incidence of contrast-induced nephropathy in patients undergoing coronary angiography. This study may shed light as to whether oral vitamin D supplementation can be an adjunct therapy in CIN patients.

Conditions

• Contrast-induced Nephropathy

Interventions

Type	Name	Description
DRUG	vitamin D3 tablets	2000 IU vitamin D3 tablets were taken daily for 6 days
DRUG	placebo	2000 IU placebo tablets were taken daily for 6 days

Timeline

• Start date: 2015-07-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2015-07-02
• Last updated: 2016-10-25

Locations

1 site across 1 country: China