NCT02488304

Prospective Study for Transplant Optimization Using Functional Imaging (TROFI)

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: FLUIDDA nv · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to detect BOS in an early stage by using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust and automated segmentation algorithms will be developed for these parameters, focusing on quantitative computed tomography (CT) image analyses to provide the physician a more sensitive diagnostics tool. The evolution of rejection over time will be monitored using non-rigid image registration methods.

Conditions

• Bronchiolitis Obliterans
• Lung Transplant Rejection

Interventions

Type	Name	Description
RADIATION	HRCT scans	A HRCT scan at Functional Residual Capacity (FRC) and Total Lung Capacity (TLC) will be taken on visit 2, visit 3, visit 4, visit 5, visit 6, and visit 7. An upper airway (UA) scan will be taken on visit 2.

Timeline

• Start date: 2015-07-01
• Primary completion: 2017-12-15
• Completion: 2017-12-15
• First posted: 2015-07-02
• Last updated: 2018-03-21

Locations

1 site across 1 country: Belgium