NCT02487381

Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids

Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids on the Endocannabinoid System, Cognition and Neuronal Oscillations

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Central Institute of Mental Health, Mannheim · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The study evaluates the gene-environment interaction of the COMT-genotype on the effects of the phytocannabinoids delta-9-tetrahydrocannabinol, cannabidiol or a combination of both on induction of psychotic symptoms, endocannabinoid levels in human body fluids, neuronal processing, and neural oscillations. In addition the effects of the phytocannabinoids on lipid levels in serum and cerebrospinal fluid, cognition, neural synchrony and neuronal processing assessed by EEG and fMRI.

Conditions

• Healthy
• Modeling Psychosis

Interventions

Type	Name	Description
DRUG	delta-9-tetrahydrocannabinol
DRUG	Cannabidiol
DRUG	Placebo

Timeline

• Start date: 2015-04-01
• Primary completion: 2015-07-01
• Completion: 2015-08-01
• First posted: 2015-07-01
• Last updated: 2015-08-17

Locations

1 site across 1 country: Germany