NCT02484651

Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?

Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade: a Randomized Controlled Study Assessing Propofol and Remifentanil Requirements and Quality of Recovery in Patients With a Standard Practice of Non-deep Rocuronium Neuromuscular Blockade Versus Deep Neuromuscular Blockade Reversed With Sugammadex

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Centro Hospitalar do Porto · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that an anesthetic protocol maintaining deep neuromuscular block throughout the entire surgical procedure followed by sugammadex reversal, would suppress EMG activity and result in improved anesthetic stability by reducing the variability of the Bispectral Index of the EEG, and be beneficial by reducing the total doses of the anesthetic drugs propofol and remifentanil required to maintain an adequate level of anesthesia (BIS between 40 and 60).

Conditions

• Neuromuscular Block

Interventions

Type	Name	Description
DRUG	Sugammadex	Reversal of deep neuromuscular block
DRUG	Rocuronium	Maintenance of deep neuromuscular block

Timeline

• Start date: 2016-09-01
• Primary completion: 2017-06-28
• Completion: 2017-07-01
• First posted: 2015-06-29
• Last updated: 2019-09-16
• Results posted: 2019-09-16

Locations

1 site across 1 country: Portugal