NCT02483663

Brain Regulation of Appetite in Twins

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 122 (actual)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and food intake. Understanding how the brain regulates appetite and food intake may eventually lead to new ways to help people avoid obesity or lose weight.

Conditions

• Obesity
• Appetite

Interventions

Type	Name	Description
DEVICE	Functional Magnetic Resonance Imaging	Measure brain activity.
RADIATION	Dual Energy X-ray absorptiometry	Body composition measurements.
OTHER	Questionnaires	Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
OTHER	Mood and Appetite Ratings	Answer questions about how you are feeling at the moment.
OTHER	Test Meals	Breakfast, a snack, and lunch provided during study visit.
OTHER	Computer Tests	Perform a series of computer tests to determine reaction time.
PROCEDURE	Intravenous Catheter (IV) placement	Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.

Timeline

• Start date: 2010-08-01
• Primary completion: 2015-08-01
• Completion: 2015-08-01
• First posted: 2015-06-29
• Last updated: 2017-10-27

Locations

1 site across 1 country: United States