NCT02482987

Comparison of Two Different Alveolar Ridge Preservation Techniques

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Eisenhower Army Medical Center · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare two barrier membrane products, Cytoplast (dPTFE) and BioXclude (human amnion chorion allograft), for their relative efficacies in dental socket preservation procedures, both when the socket is filled and overfilled with freeze dried bone allograft (FDBA).

Detailed description

This single-blind, randomized clinical trial aims to compare two different, commercially available materials to assess their relative efficacies in socket preservation procedures after tooth extraction. Patients presenting with single teeth deemed clinically hopeless and treatment planned for removal in the normal course of clinical dentistry will be considered for this study. If eligible, a ridge/socket preservation procedure will be performed at the time of extraction. Periodontics residents will perform the procedure under the supervision of board certified staff. Patients will be randomized via concealed random number sequence into one of four groups, based on a combination of materials and graft placement techniques. Patients will be equally distributed into the following groups: (1) dense polytetrafluoroethylene (Cytoplast) (2) Cytoplast with additional buccal augmentation/onlay graft, (3) human amniotic-tissue derived membrane (BioXclude), and (4) BioXclude with additional buccal augmentation/onlay graft. All four treatment groups are consistent with the current standard of care, and this study seeks to compare techniques and materials as part of routine, clinical/periodontal therapy in order to determine superiority. Approximately 150 patients will be enrolled and distributed equally among the four groups. Any post-operative complications will be managed and documented during follow-up appointments at 1, 2 and 4 weeks. Cone beam computed tomography (CBCT) will be used as the primary assessment tool, and scans will be compared between a pre-operative baseline time point and a scan taken after 4 months of healing to prepare for implant placement. The primary dependent variables will be (1) percent of baseline alveolar ridge changes (both horizontal and vertical) and (2) whether or not the anticipated dental implant could be placed appropriately. Secondary outcomes include ease of use, perceptions of pain, complications, cost-effectiveness, and changes in keratinized tissue.

Conditions

• Loss of Teeth Due to Extraction

Interventions

Type	Name	Description
DEVICE	dense polytetrafluoroethylene (dPTFE) membrane Cytoplast	ridge preservation intervention using the dPTFE membrane device
DEVICE	human amniotic-tissue derived membrane BioXclude	ridge preservation intervention using the dPTFE membrane device
PROCEDURE	Ridge Preservation with overlay graft	ridge preservation intervention with additional freeze dried bone allograft (FDBA) placed buccal to the socket
PROCEDURE	Ridge Preservation without overlay graft	ridge preservation without overlay graft / traditional FDBA placement into the socket only

Timeline

• Start date: 2015-07-01
• Primary completion: 2018-07-01
• Completion: 2018-07-01
• First posted: 2015-06-26
• Last updated: 2017-02-07

Locations

1 site across 1 country: United States