NCT02482818

Efficacy of Pregabalin on Chronic Cough

Efficacy of Pregabalin on Chronic Cough: A Double Blind, Randomized Control Trial Comparing Pregabalin With Placebo in Patients With Non-asthmatic Chronic Cough

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Ottawa Hospital Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 84 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if Pregabalin, a medication used for the treatment of seizures and chronic pain, can be used to effectively treat people who suffer from non-asthmatic chronic cough (cough lasting over 8 weeks).

Detailed description

A significant number of patients have an impaired quality of life due to chronic cough that fails to respond to therapeutic efforts. Research suggests that patients with chronic cough may have an oversensitive cough reflex. Reflexes are involuntary responses to nerve stimulation. Since standard cough medicines may not be helpful for treating the oversensitive cough reflex, treatment with neurologically acting agents has been investigated. Existing work in treatment of cough of unknown etiology has focused on the use of Gabapentin, a compound that acts neurologically that is used in the treatment of epilepsy and pain. A similar drug, Pregabalin, may be a superior medication for this indication. Pregabalin is rapidly absorbed with peak blood concentrations within 1 hour, has an approximate bioavailability of 90%, and is 3 to 10 times more potent than Gabapentin and has no known pharmacokinetic drug interactions.

Conditions

• Cough

Interventions

Type	Name	Description
DRUG	Pregabalin	Increasing dose regimen depending on tolerability followed by decreasing dose regimen.
DRUG	Control-Placebo	A control substance, Lactose is administered in place of Pregabalin.

Timeline

• Start date: 2015-09-01
• Primary completion: 2021-12-31
• Completion: 2021-12-31
• First posted: 2015-06-26
• Last updated: 2020-09-25

Locations

1 site across 1 country: Canada