NCT02481336

To Study the Individual Variants of Chemotherapy-Induced Neurotoxicity

Integrating Clinical and Genomic Profiles for Prediction and Prevention of Chemotherapy-induced Neuropathy Via Big Bio-Data Analytics

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: National Cheng-Kung University Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

To study the risk prediction of chemotherapy-induced peripheral neuropathy (CIPN) by the clinical bioinformatics and genomic profile.

Detailed description

This is a prospective, observational, cohort study, monitoring the chemotherapy-induced peripheral neurotoxicity by traditional clinical scales, neurological examinations, and semi-quantitative assessments. Moreover, all the genetic changes will be analyzed by next generation sequencing and we will try to identify relevant variants in individuals who suffer from chemotherapy-induced neurotoxicity.

Conditions

• Neurotoxicity Syndromes

Interventions

Type	Name	Description
OTHER	Questionnaires	EORTC CIPN20 and EQ-5D-3L
PROCEDURE	Peripheral nervous system examination	nerve conduction velocity (NCV), quantitative sensory test (QST), and nerve excitability test (NET)
GENETIC	Whole Genome Sequence	Genetic Test : 10 mL blood will be collected in Blood Sample Collection

Timeline

• Start date: 2015-03-01
• Primary completion: 2029-12-31
• Completion: 2029-12-31
• First posted: 2015-06-25
• Last updated: 2026-04-14

Locations

1 site across 1 country: Taiwan