NCT02479529

Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 130 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

After cardiac surgery, vasoplegic syndrome is a hemodynamic state characterized by profound hypotension associated with a decrease in systemic vascular resistance. The care of this disease is based on the intravenous administration of a vasopressor, usually norepinephrine. During the recovery phase, weaning of norepinephrine, is an important step in which any lack of preload (blood volume) initial or secondary can be, and increase tissue malperfusion.

Conditions

• Vasoplegic Syndrome

Interventions

Type	Name	Description
DRUG	Norepinephrine	Administration and weaning of norepinephrine is based on dynamic arterial elastance
DRUG	Norepinephrine	The usual procedure of withdrawal norepinephrine is based on hemodynamic parameters (blood pressure, cardiac output), clinical (cutaneous perfusion, mottling, hourly diuresis) and biological (SVO2, arterial lactate).

Timeline

• Start date: 2014-10-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2015-06-24
• Last updated: 2025-09-22

Locations

1 site across 1 country: France