NCT02475421

Hyperglucagonaemia in Patients With Type 2 Diabetes - Role of Glucagon Clearance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The study aims to evaluate the elimination and degradation of glucagon in patients with type 2 diabetes compared to matched healthy subjects.

Detailed description

In the present project the investigators wish to identify whether the elimination and degradation of glucagon differ between healthy control subjects and patients with type 2 diabetes. Furthermore, the investigators wish to examine whether obesity is an independent factor for altered glucagon metabolism. Thus, by examining glucagon elimination in obese subjects with and without type 2 diabetes and in lean subjects with and without type 2 diabetes the investigators will be able to describe the metabolic clearance rate (MCR) of glucagon in a broad spectrum of individuals with different levels of insulin resistance and beta cell dysfunction.

Conditions

• Diabetes

Interventions

Type	Name	Description
BIOLOGICAL	Glucagon	One hour glucagon-clamp followed by one hour of blood sampling

Timeline

• Start date: 2015-05-01
• Primary completion: 2016-12-01
• Completion: 2017-01-01
• First posted: 2015-06-18
• Last updated: 2018-10-15

Locations

1 site across 1 country: Denmark