NCT02474264

The Link Between BRCA Mutation and Endothelial Function

The Link Between BRCA Mutation and Endothelial Function - A Pilot Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (estimated)
• Sponsor: Rabin Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effect of BRCA1\&2 mutations on cardiovascular diseases by to comparing the endothelial function of male BRCA mutation carriers with that of age matched non-BRCA mutation carriers.

Conditions

• BRCA1 Gene Mutation
• BRCA2 Gene Mutation

Interventions

Type	Name	Description
OTHER	Endothelial function assessment	reactive hyperemia index
OTHER	Cardiovascular biomarkers	Cardiovascular biomarkers will be measure to test other aspects of endothelial and cardiac function: high-sensitivity troponin (hsTn) , C-reactive protein , D-dimer, N-terminal pro-brain natriuretic peptide (NT-proBNP)
OTHER	Endothelial cells	Endothelial Progenitor Cells and Circulating Endothelial Cells profiles- will be characterized to evaluate endothelial injury.

Timeline

• Start date: 2015-02-01
• Primary completion: 2018-07-01
• Completion: 2018-11-01
• First posted: 2015-06-17
• Last updated: 2017-07-18

Locations

1 site across 1 country: Israel