Trials / Completed
CompletedNCT02471586
OPTIMIZE PCI: Multicenter Randomized Trial of OCT Compared to IVUS and Angiography to Guide Coronary Stent Implantation
ILUMIEN III: OPTIMIZE PCI: OPtical Coherence Tomography (OCT) Compared to Intravascular Ultrasound (IVUS) and Angiography to Guide Coronary Stent Implantation: a Multicenter RandomIZEd Trial in Percutaneous Coronary Intervention (PCI)
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 450 (actual)
- Sponsor
- Abbott Medical Devices · Industry
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The objective of this clinical investigation is to demonstrate the safety and efficacy of an OCT guided strategy for stent implantation
Detailed description
This is a prospective, post-market, international, multi-center, randomized clinical investigation in which the participants will be randomized in 1:1:1 ratio to undergo PCI with either OCT, IVUS, or Angiography guidance. The clinical investigation will be conducted at approximately 35 sites in the United States and outside the United States; approximately 25% of subjects will be enrolled in the United States. Patients in the IVUS and OCT groups patients will undergo baseline and post PCI imaging with their randomized modality. In addition, the Angiography group and IVUS groups will undergo a blinded post-PCI OCT run to allow comparison of OCT derived minimum stent area (MSA) in both groups. After hospital discharge, all patients will have clinical follow-up at 30 days, and 1 year.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Coronary PCI guided by IVUS | Imaging type |
| PROCEDURE | Coronary PCI guided by OCT | Imaging type |
| PROCEDURE | Coronary PCI guided by Angiography | Imaging type |
Timeline
- Start date
- 2015-05-01
- Primary completion
- 2016-04-05
- Completion
- 2017-04-25
- First posted
- 2015-06-15
- Last updated
- 2021-04-01
- Results posted
- 2021-04-01
Locations
29 sites across 8 countries: United States, Belgium, Germany, Italy, Japan, Netherlands, Spain, United Kingdom
Source: ClinicalTrials.gov record NCT02471586. Inclusion in this directory is not an endorsement.