NCT02468531

Xenon Against Postoperative Oxygen Impairment

Protection of Xenon Against Postoperative Oxygen Impairment in Adults Undergoing Stanford Type-A Acute Aortic Dissection Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Beijing Anzhen Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system. Furthermore, our earlier trial has already clarified that static inflation with 50% Xenon during cardiopulmonary bypass could attenuate ALI for Standford A acute aortic dissection. However the protection effect was restricted for the limited time. Aimed to enhance the protection effect of Xenon, we designed this randomized trial that anesthesia with 50% xenon one hour before and after CPB and pulmonary static Inflation with 50%,75% and 100% Xenon during CPB respectively.

Conditions

• Acute Lung Injury

Interventions

Type	Name	Description
OTHER	oxygen	50% oxygen inhalation
DRUG	Xenon	50% Xenon inhalation

Timeline

• Start date: 2015-01-01
• Primary completion: 2017-07-01
• Completion: 2017-12-01
• First posted: 2015-06-11
• Last updated: 2016-11-09

Locations

1 site across 1 country: China