NCT02468063

To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock

A Prospective Study to Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 184 (actual)
• Sponsor: Institute of Liver and Biliary Sciences, India · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level study. The investigators will strictly follow the randomization table to give therapy as per the intervention arm. * Intervention:-the therapeutic intervention is vasopressor i.e. noradrenaline alone and terlipressin along with noradrenaline to maintain the MAP \>65mm Hg. * Intervention arm * Arm (A) - Noradrenaline * Arm (B) - Noradrenaline + low dose terlipressin

Conditions

• Cirrhosis With Septic Shock

Interventions

Type	Name	Description
DRUG	Low dose terlipressin	Terlipressin-2mg (low dose )
DRUG	Noradrenaline	Noradrenaline at 7.5 mcg/min, maximum of 60mcg/min. stepped up every 15 min
DRUG	Noradrenaline	Noradrenaline- 3.75 mcg/min to 30 mcg/min. stepped up every 15 min

Timeline

• Start date: 2015-05-01
• Primary completion: 2017-05-31
• Completion: 2017-05-31
• First posted: 2015-06-10
• Last updated: 2017-11-06

Locations

1 site across 1 country: India