NCT02467556

Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Helsinki University Central Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

A ten week open label study intervention to evaluate the outcome for a psychological intervention combined with physiotherapy and medication with memantine-morphine in 10 CRPS patients.

Detailed description

Ten CRPS I patients attended an intervention for 10 weeks. First, the medication was started with morphine 10mg adding gradually to 30 mg per day. Then, in addition to morphine, memantine 5 mg was started adding the dose gradually up to 40 mg per day if tolerated. Physiotherapy and psychological intervention were mostly carried out in a weekly group gathering with home exercises that were recorded to a diary. Psychological and physiotherapy interventions lasted for eight weeks. A neurological examination was done before and after the intervention as well as a separate physiotherapist examination of the hands. Patients filled out questionnaires of mood, quality of life, pain, and CRPS descriptions before and after the intervention.

Conditions

• CRPS

Interventions

Type	Name	Description
DRUG	Morphine, memantine	Morphine up to 30 mg per day orally and memantine up to 40 mg per day orally if tolerated for 10 weeks.
BEHAVIORAL	Psychological intervention	To help patients shift perspective from pain and CRPS-symptoms, to increase body awareness, to create vivid imagenary, to increase the use of a CRPS hand with mindfulness exposure exercises, to increase flexibility in behavioral repertoire, to explore the fusion of emotions, automatic cognitions and learned responses and to help patients to integrate new skills in their lives.
OTHER	Physiotherapy intervention	Graded motor imagenary with group and individual weekly sessions with daily practices at home.

Timeline

• Start date: 2011-03-01
• Primary completion: 2014-05-01
• Completion: 2014-06-01
• First posted: 2015-06-10
• Last updated: 2020-03-24

Locations

1 site across 1 country: Finland