NCT02465554

Imaging and Omics for Cardiovascular Risk During NASA Deep Space Missions

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: All
• Age: 35 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to develop new approaches for screening astronauts for cardiovascular risk during deep space missions.

Detailed description

The purpose of this study is to develop new approaches for screening astronauts for cardiovascular risk during deep space missions. In this protocol, two different forms of imaging will be used to evaluate coronary plaque development (CT coronary angiography) and microvascular function (myocardial contrast echocardiography) to stratify CV risk. Based on this stratification, "omic" patterns (targeted metabolomics, lipidomic, and whole genome sequencing) will be assessed to determine whether there are any patterns that can add to existing predictive models. Outcomes measures will involve correlation of "omic" patterns to incremental risk scaling from lowest (no plaque and normal endothelial function) to highest (+ plaque and endothelial dysfunction).

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
PROCEDURE	Myocardial contrast echocardiography	Myocardial contrast echocardiography will be performed to further stratify risk as described in the cohort section.

Timeline

• Start date: 2015-09-01
• Primary completion: 2017-12-31
• Completion: 2018-12-01
• First posted: 2015-06-08
• Last updated: 2018-01-12

Locations

1 site across 1 country: United States