Trials / Completed
CompletedNCT02463409
Theophylline as a Treatment for Children With Pseudohypoparathyroidism Type 1a (Albright Hereditary Osteodystrophy)
Effects of Theophylline on cAMP Signaling in Children With Pseudohypoparathyroidism Type 1a
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 6 (actual)
- Sponsor
- Vanderbilt University Medical Center · Academic / Other
- Sex
- All
- Age
- 10 Years – 21 Years
- Healthy volunteers
- Not accepted
Summary
This study will test an investigational drug, theophylline, in children with pseudohypoparathyroidism type 1a (PHP1a). This study involves a 3 day visit to the Vanderbilt Clinical Research Center.
Detailed description
Study measures will be done at baseline and during a 24h infusion of IV theophylline. Theophylline levels will be drawn to ensure therapeutic dosing and to monitor for toxicity. Measures include laboratory values, response to PTH infusion and resting energy expenditure.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Theophylline | 24 hour infusion of IV theophylline |
Timeline
- Start date
- 2015-06-01
- Primary completion
- 2016-10-01
- Completion
- 2016-10-01
- First posted
- 2015-06-04
- Last updated
- 2017-06-26
- Results posted
- 2017-05-30
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02463409. Inclusion in this directory is not an endorsement.