NCT02461082

EMST and TMS for Treatment of Dysphagia in Parkinson's Disease

Expiratory Muscle Strength Training (EMST) and Transcranial Magnetic Stimulation (TMS) for Treatment of Swallowing Disorders in Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: University Hospital Muenster · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to examine the effectiveness of different methods for the treatment of dysphagia in Parkinson's disease (PD). More than 80% of patients suffering from PD develop dysphagia during the course of their disease leading to malnutrition, loss of life quality, weight loss and pneumonia, which is the leading cause of death in these patients. So far, only a few specific treatment approaches have been investigated in PD patients with swallowing disorders. The investigator want to compare a 4-week expiratory muscle strength training (EMST), transcranial magnetic stimulation (TMS), and combination of both with a sham therapy. Dysphagia severity before and after intervention is measured by flexible endoscopic evaluation of swallowing (FEES). For the evaluation of changes in cortical swallowing processing the investigators apply magnetoencephalography (MEG).

Conditions

• Parkinson's Disease

Interventions

Type	Name	Description
DEVICE	Expiratory muscle strength training (EMST)	The EMST is performed 4 weeks, 5 days per week, for 20 minutes per day, using a calibrated or sham, handheld device (EMST 150, Aspire Products, Gainesville, FL).
OTHER	Transcranial magnetic stimulation (TMS)	A sham or active transcranial magnetic stimulation is performed at the last 5 days of EMST training.

Timeline

• Start date: 2015-05-01
• Primary completion: 2018-04-06
• Completion: 2018-08-28
• First posted: 2015-06-03
• Last updated: 2018-09-24

Locations

1 site across 1 country: Germany