NCT02460835

A Pilot Study of Individualized Adaptive Radiation Therapy for Hepatocellular Carcinoma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: University of Michigan Rogel Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot single arm study with the primary endpoints of feasibility and preliminary estimates of safety and efficacy. This protocol builds on over 25 years of experience with high dose liver RT (Radiation Therapy), and in particular adaptive RT aimed at adjusting the global radiation dose based on a patient's measured sensitivity to treatment. This current protocol uses functional imaging and specialized radiation planning techniques to spare highly functional portions of the liver to preserve function. The investigators feel this will further improve the safety and efficacy of RT for all patients by customizing treatments to each. If this approach is promising, the investigators will proceed to a phase II randomized study of standard versus spatially and dosimetrically adapted RT.

Conditions

• Hepatocellular Carcinoma

Interventions

Type	Name	Description
RADIATION	Adaptive Radiation Therapy

Timeline

• Start date: 2016-01-26
• Primary completion: 2022-01-20
• Completion: 2022-01-20
• First posted: 2015-06-02
• Last updated: 2023-11-15
• Results posted: 2023-11-15

Locations

1 site across 1 country: United States