NCT02458547

Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 186 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial. Due to old age, poor patient condition and emergent clinical settings, patients undergoing surgical procedures for hip fracture management are often subject to poor postoperative outcome and high mortality rates. While many studies have reported that regional anesthesia leads to improved postoperative outcome after hip fracture surgery, others have concluded otherwise. Moreover, because the majority of these previous studies are retrospective cohorts or systemic reviews, there is a need for randomized clinical trials to provide high quality evidence. This study aims to compare patient outcome between three different anesthetic techniques in elderly patients undergoing surgery for hip fracture management by evaluating proinflammatory cytokines, chemistry lab testing and clinical outcome between general anesthesia with either desflurane or propofol-based TIVA and spinal anesthesia with bupivacaine.

Conditions

• Hip Fracture

Interventions

Type	Name	Description
DRUG	Desflurane	Inhalation anesthesia with desflurane at age-adjusted MAC of 0.8\~1.0
DRUG	Propofol	Total intravenous anesthesia with propofol target controlled infusion
DRUG	Bupivacaine	Spinal anesthesia with 0.5% bupivacaine

Timeline

• Start date: 2015-05-01
• Primary completion: 2019-01-21
• Completion: 2019-01-21
• First posted: 2015-06-01
• Last updated: 2019-03-19

Locations

1 site across 1 country: South Korea