NCT02454868

Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Brasilia University Hospital · Academic / Other
• Sex: All
• Age: 2 Years – 9 Years
• Healthy volunteers: Accepted

Summary

Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for adequate intubation conditions as defined by previous studies.

Detailed description

Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for adequate intubation conditions as defined by previous studies. Remifentanil doses starting from 2mg/kg will be infused before intubation. When a success occurs next patient's dose will be decreased by 0.25mg/kg/h. When a success does not occur the next patient's dose will be increased by 0.25mg/kg/h. Intubation will be considered adequate if patient does not cough, does not move, if vocal cords are open, if larigocsocpic Cormack grade I or II.

Conditions

• Underdosing of Unspecified General Anesthetics

Interventions

Type	Name	Description
DRUG	Remifentanil	Remifentanil for intubation without neuromuscular blockade

Timeline

• Start date: 2016-07-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2015-05-27
• Last updated: 2016-07-19