NCT02454127

Effectiveness of Four Popular Diet Strategies for Weight Loss and Cardiac Risk Reduction

Effectiveness of Four Dietary Treatment Strategies for Metabolic Syndrome: a Prospective Randomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Tufts Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia. Participants were enrolled starting July 18, 2000, and randomized to 4 popular diet groups until January 24, 2002.

Detailed description

Objective: To assess adherence rates and the effectiveness of 4 popular diets (Atkins, Zone, Weight Watchers, and Ornish) for weight loss and cardiac risk factor reduction. Design, Setting, and Participants: A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia. Participants were enrolled starting July 18, 2000, and randomized to 4 popular diet groups until January 24, 2002. Intervention: A total of 160 participants were randomly assigned to either Atkins (carbohydrate restriction, n=40), Zone (macronutrient balance, n=40), Weight Watchers (calorie restriction, n=40), or Ornish (fat restriction, n=40) diet groups. After 2 months of maximum effort, participants selected their own levels of dietary adherence. Main Outcome Measures: One-year changes in baseline weight and cardiac risk factors, and self-selected dietary adherence rates per self-report. Outcome measures included body weight, total cholesterol, LDL-C, HDL-C, triglycerides, hsCRP, insulin, glucose.

Conditions

• Obesity
• Cardiovascular Disease
• Metabolic Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Atkins Diet	Dietary counseling for 1 year
BEHAVIORAL	Zone Diet	Dietary counseling for 1 year
BEHAVIORAL	Weight Watchers Diet	Dietary counseling for 1 year
BEHAVIORAL	Ornish Diet	Dietary counseling for 1 year

Timeline

• Start date: 2000-07-01
• Primary completion: 2003-01-01
• Completion: 2004-01-01
• First posted: 2015-05-27
• Last updated: 2016-10-31
• Results posted: 2016-10-31