NCT02452229

Review of Human Herpes Viruses in Burns

Human Herpes Viruses in Burn Victims: A Systematic Review

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 10,267 (actual)
• Sponsor: The University of Texas Medical Branch, Galveston · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Detailed description

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist. We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search. On the PubMed interface, we used the following search terms: ("HSV"\[All Fields\] OR "herpes"\[All Fields\] OR "CMV"\[All Fields\] OR "cytomegalovirus"\[All Fields\] OR "VZV"\[All Fields\] OR "varicella-zoster"\[All Fields\]) AND ("burns"\[MeSH Terms\] OR "burns"\[All Fields\] OR "burn"\[All Fields\] OR "thermal trauma"\[All Fields\]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A\&HCI, CPCI-S.

Conditions

• Human Herpes Virus
• Herpes Simplex Virus
• Varicella-zoster Virus
• Chickenpox
• Cytomegalovirus
• Burns

Interventions

Type	Name	Description
OTHER	Review of the Literature for Human Herpes Virus infections	Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface. PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-05-01
• First posted: 2015-05-22
• Last updated: 2015-05-22