NCT02452125

The Effects of Nicotine Chewing Gum in Parkinson's Disease

The Effects of Nicotine Chewing Gum on Acute Low Blood Pressure in Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: New York Institute of Technology · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The objective of this experiment is: To determine if nicotine chewing gum will improve acute episodes of orthostatic hypotension in PD subjects.

Detailed description

Subjects will be asked to sit and rest for 10 minutes. Blood pressure will be taken in this resting position after the 10 minutes. After all inclusion criteria has been met, subjects will then wear an automated BP cuff and be administered 4mg of nicotine gum (Nicorette™). They will be instructed to use it according to manufacturer's directions and remain chewing the gum for 30 minutes. The subject will remain in a seated position and BP and HR will be recorded every 5 minutes for 30 minutes. After 30 minutes the gum will be removed and subjects will still have HR and BP monitored in the seated position for another hour every 10 minutes. All values will be compared to pretreatment values. After 120 minutes if the subject is non-symptomatic, they can go home.

Conditions

• Low Blood Pressure
• Parkinsons Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Nicotine gum	Nicotine chewing gum

Timeline

• Start date: 2015-05-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2015-05-22
• Last updated: 2017-07-28

Locations

1 site across 1 country: United States