NCT02451904

Severe and Cerebral Malaria Investigated Through Host Metabolomics

Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 840 (actual)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Accepted

Summary

* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. * Despite treatment between 10-30% of patients with severe malaria die. * Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood. * Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

Conditions

• Severe Malaria

Interventions

Type	Name	Description
OTHER	Observation

Timeline

• Start date: 2015-06-01
• Primary completion: 2017-09-01
• Completion: 2017-09-01
• First posted: 2015-05-22
• Last updated: 2018-06-20

Locations

1 site across 1 country: Bangladesh