NCT02451072

The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers

The Role of 5-HT2A Receptor on Perception of the Self and Perception of Meaning in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Psychiatric University Hospital, Zurich · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Aim of the present study is to investigate the neuronal correlates of self and of personal meaning as well as the role of the serotonin (5-HT) 2A receptor system in these processes using functional magnetic resonance imaging (fMRI) and psychometric and cognitive measures.

Detailed description

The present study aims at identifying the contribution of the 5-HT2A receptor system to the formation of self and personal meaning in normal and altered states of consciousness. Specifically, the effect of the 5-HT2/1/6/7 receptor agonist lysergic acid diethylamide (LSD) on self-consciousness, perception and the making of meaning will be assessed in 25 healthy subjects using a randomized, placebo-controlled, double blind, cross-over design. Furthermore, the contribution of the 5-HT2A receptor to these functions shall be assessed by pretreatment with the specific 5-HT2A antagonist ketanserin.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Placebo	Capsules containing mannitol looking identical to LSD per os
DRUG	LSD	100µg per os, single dose
DRUG	Ketanserin	40mg per os, single dose looking identical to LSD per os

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-01-01
• Completion: 2016-01-01
• First posted: 2015-05-21
• Last updated: 2016-02-01

Locations

1 site across 1 country: Switzerland