NCT02449382

Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia

To Effect and Safety of Continuous Venovenous Hemofiltration (CVVH) Versus Conventional Treatment for Acute Severe Hypernatremia in Critical Ill Patients: A Randomized Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Air Force Military Medical University, China · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system. Several case reports demonstrated that CVVH could effectively decrease serum sodium concentration of the patients with severe hypernatremia. The use of CVVH for acute severe hypernatremia in critically ill patients could improve patient survival by effectively decreasing the serum sodium concentration to a normal level.

Detailed description

Date collection: 1. Demographic (gender, age, race, weight, history of drug allergy, complicating diseases, drug combination and combination therapy) 2. CVVH treatment (time, blood vessel, blood flow, replacement fluid flow, the type and dose of anticoagulant, limited to the test group) 3. Vital signs (blood pressure, heart rate, respiratory frequency, body temperature) 4. Severity of disease 5. General treatment (Vasoactive drugs, mechanical ventilation, diuretic, steroid hormones) 6.24 hours input 7.24 hour output 8.Daily sodium intake 9.Adverse events were confirmed 10.Laboratory date: Routine blood test Blood biochemical Blood gas analysis Blood electrolyte Plasma osmotic pressure Urine osmotic pressure Plasma osmotic pressure Urinary electrolyte excretion fraction

Conditions

• Hypernatremia
• Critically Ill

Interventions

Type	Name	Description
PROCEDURE	continuous venovenous hemofiltration	If the serum sodium concentration \>150mmol/L, When filter occurred clotting, replace the filter to CVVH treatment
DRUG	Control group	If the serum sodium concentration ≤150mmol/L, When filter occurred clotting, as the end of treatment.

Timeline

• Start date: 2015-06-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2015-05-20
• Last updated: 2015-07-13

Locations

1 site across 1 country: China