NCT02447627

Study of Methodologies to Measure Blood Flow and Oxygenation in Adults With Sickle Cell Disease

A Study of Methodologies to Measure Blood Flow and Oxygenation as Potential Biomarkers in Adults With Sickle Cell Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: Bioverativ Therapeutics Inc. · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to determine whether imaging techniques, such as magnetic resonance imaging (MRI), near infrared spectroscopy (NIRS), laser speckle contrast imaging (LSCI), and optical imaging (OI), can detect differences in blood flow and oxygen levels in different organ systems of participants with sickle cell disease (SCD). Differences in blood flow and oxygen levels detected by these techniques will be evaluated to determine their utility as biomarkers of clinical disease pathophysiology.

Conditions

• Healthy
• Sickle Cell Disease

Timeline

• Start date: 2015-06-01
• Primary completion: 2016-10-01
• Completion: 2016-10-01
• First posted: 2015-05-19
• Last updated: 2020-12-19

Locations

1 site across 1 country: United States