NCT02445547

Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease

Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Fuzhou General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Stem cell transplantation has emerged as a relatively popular treatment that can help to regulate immunity, repair injury, and control inflammation. Several studies have used autologous stem cells or adipose-derived stem cells to treat Crohn's disease and its associated complications, and have achieved good efficacy. Thus far, the use of umbilical cord mesenchymal stem cells (UC-MSCs) to treat Crohn's disease has rarely been reported. In this study, UC-MSCs were used to treat patients with hormone-controlled Crohn's disease. We observed the disease control conditions, corticosteroid dosage changes, and treatment-related adverse reactions.

Conditions

• Crohn Disease

Interventions

Type	Name	Description
OTHER	UC-MSCs by peripheral intravenous infusion
DRUG	received hormone maintenance therapy

Timeline

• Start date: 2012-06-01
• Primary completion: 2015-06-01
• First posted: 2015-05-15
• Last updated: 2017-01-18

Locations

1 site across 1 country: China