NCT02439801

Comparison of Effects of PEEP Levels on Respiratory Mechanics in Patients Undergoing Laparoscopic Cholecystectomy

Comparison of Effects of 3 Different PEEP Levels on Hemodynamic, Respiratory Mechanics and Elimination of Volatile Anesthetic Agent in Patients Undergoing Laparoscopic Cholecystectomy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 75 (actual)
• Sponsor: Umraniye Education and Research Hospital · Other Government
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Laparoscopic cholecystectomy is accepted as gold standard in the management of cholelithiasis. Although laparoscopic procedures have many advantages,intra-abdominal CO2 insufflation can cause decreased lung volumes and compliance, increased airway resistance and impaired ventilation-perfusion ratio. In this study, investigators aim to investigate effects of intra-operative PEEP treatment at 3 distinct levels on respiratory dynamics and elimination time of volatile anesthetic agent.

Detailed description

In the study, 75 ASA I-II patients aged 30-65 years will be randomized into 3 groups to receive 0 cmH2O PEEP (Group-1), 5 cmH2O PEEP (Group-2) and 8 cmH2O PEEP (Group-3) in PVC mode. In all patients underwent general anesthesia; hemodynamic parameters, Ppeak, Pplateau, compliance values as well as Fisevo/Fexpsevo ratio at 1 MAC and times from 1 MAC to 0.3 and 0.1 MAC will be recorded. In addition, preoperative and postoperative pulmonary function tests will be compared in all patients.

Conditions

• Respiratory System Abnormalities

Interventions

Type	Name	Description
PROCEDURE	PEEP 0	0 cmH2O positive end expiratory pressure
PROCEDURE	PEEP 5	5 cmH2O positive end expiratory pressure
PROCEDURE	PEEP 8	8 cmH2O positive end expiratory pressure

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-05-01
• Completion: 2015-05-01
• First posted: 2015-05-12
• Last updated: 2015-05-12

Locations

1 site across 1 country: Turkey (Türkiye)