NCT02435667

Resistance Training in HFpEF

Resistance Exercise Training in Heart Failure With Preserved Ejection Fraction (Resist - HFpEF)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The objective of this proposal is to determine the effect of resistance exercise training on locomotor muscle function, exercise capacity, exertional symptoms, and quality of life in HF patients with preserved ejection fraction (HFpEF).

Detailed description

In this randomized controlled pilot study of resistance exercise training in patients with HFpEF, the investigators will recruit 24 HFpEF patients who will be randomized to resistance exercise training (RT - n=12) or no resistance exercise training (standard care control group \[CTL\] - n=12). The investigators will have baseline and follow-up measures of clinical characteristics, leg muscle strength, quality of life, lean muscle mass (body composition via DXA including segmental lean mass), maximal cardiopulmonary exercise test (peak VO2, peak work, ventilatory efficiency), constant-load submaximal cardiopulmonary exercise test with speckle tracking echocardiography (exertional dyspnea and fatigue at matched workloads, cardiac output, diastolic function, left ventricular strain, ventilation, gas exchange, and locomotor muscle neural feedback). Participants will be asked to make 4 separate study visits. Those randomized to undergo Resistance Training will be expected to make those visits as well.

Conditions

• Heart Failure Preserved Ejection Fraction

Interventions

Type	Name	Description
OTHER	Resistance Exercise Training	1. Aerobic Exercise a. Each participant will engage in 5 minutes of aerobic based exercise on an arm/leg ergometer (NuStep Cross Trainer) at an intensity of 12-14 on the Borg Rating of Perceived Exertion Scale as a warm-up prior to the exercise session and again as a cool-down at the end of the exercise session. 2. Resistance Exercise - 2 sets of 8-12 repetitions - beginning at 60% of the initial 1 RM. a) Leg Extension, b) Bicep Curl, c) Leg Press, d) Chest Press, e) Leg Curl, f)Seated Row (horizontal or pulldown), g) Calf Raises 3. Core Strengthening Exercises a. 5-10 minutes of stability ball and balance exercises
RADIATION	DEXA bone scan	A DEXA scan that provides bone density measures.
OTHER	Cardiopulmonary Max Exercise Test	Pedaling on a cycle ergometer to volitional fatigue.
OTHER	Quality of Life Questionnaire	A 10 minute questionnaire that measures quality of life.
OTHER	Submaximal Exercise Test	Two short submaximal constant-load exercise sessions at 20 Watts. Each session will include 6 minutes of cycling (baseline). Following baseline, the sessions will be randomized to continued constant-load cycling for an additional 9 minutes (for echocardiographic measures) or randomized sub-systolic inflation of bilateral thigh pressure tourniquets to 40 and 80 mmHg for 3 minutes with 3 minutes of deflation between inflations to stimulate locomotor muscle neural feedback.
OTHER	Blood Draw	A blood draw amounting to 1 teaspoon of blood drawn.

Timeline

• Start date: 2015-06-01
• Primary completion: 2021-01-01
• Completion: 2021-01-01
• First posted: 2015-05-06
• Last updated: 2021-02-03

Locations

1 site across 1 country: United States