Trials / Terminated
TerminatedNCT02435550
iCare for Cancer Patients
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 136 (actual)
- Sponsor
- University of Florida · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to use genomic information from individual patients to create simulation avatars that will be used to predict novel drug combinations with therapeutic potential.
Detailed description
As part of normal clinical care, subjects will undergo peripheral blood draws and biopsies for disease assessment of their cancer. In cases of hematological malignancies, bone marrow aspiration \& biopsy are routinely performed. As part of this project, the following will be done to the samples collected and with clinical outcomes data: * donate peripheral blood specimens whenever blood is already being drawn for clinical purposes. * donate bone marrow aspiration samples whenever a bone marrow aspiration procedure is already being done for clinical purposes. * donate saliva whenever blood draw is already being done for clinical purposes. * allow the investigators to perform gene mutation profiling. * allow the investigators to study gene mutation results. * allow the investigators to perform pharmacogenetic profiling. * allow the investigators to study pharmacogenetic profiles. * allow the investigators to examine chromosome copy number variations. * allow the investigators to examine genomic methylation. * allow the investigators to quantify metabolomics/cytokines.
Conditions
- Myelodysplastic Syndromes
- Acute Myeloid Leukemia
- Acute Myelogenous Leukemia
- Acute Lymphoid Leukemia
- Leukemia, Acute Lymphoblastic
- Multiple Myeloma
- Myelofibrosis
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | Molecular diagnostic testing | Molecular diagnostic testing will be performed on peripheral blood, bone marrow aspirate and saliva samples that will be collected from each patient as part of routine care. Tests performed may include: cytogenetics, FISH, chromosome copy number variation, next generation DNA sequencing, methylation, and metabolomics. |
Timeline
- Start date
- 2015-06-26
- Primary completion
- 2019-10-01
- Completion
- 2019-10-01
- First posted
- 2015-05-06
- Last updated
- 2019-12-20
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02435550. Inclusion in this directory is not an endorsement.