NCT02434679

Dynamic of the Acquisition of Antibiotic Resistance in Integrons in Neonatology Newborns

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 278 (actual)
• Sponsor: University Hospital, Limoges · Academic / Other
• Sex: All
• Age: 1 Day
• Healthy volunteers: Not accepted

Summary

Antibiotic resistance is a major public health issue as multiresistant bacteria (MRB) are increasing. Among the actions to control resistance, one is an interesting lead: to prevent the emergence of resistant bacteria by limiting possibilities for bacteria to acquire resistance. Mechanisms of resistance genes acquisition are deeply studied but there are few data on the dynamic of acquisition over time. Among the genetic components that disseminate resistance genes, resistance integrons (RI) play a major role in the acquisition and dissemination of antibiotic resistance in gram-negative bacteria. The digestive tract of the newborn (NB), which is initially sterile, is colonized by a bacterial microbiota during the first days of life. It thus appears to be an appropriate model to study the dynamic of resistance acquisition. This project intends to follow the NB of neonatology over time in order to study the dynamic of the digestive acquisition of RI and MRB

Conditions

• Bacteriology

Timeline

• Start date: 2014-10-01
• Primary completion: 2016-02-01
• Completion: 2016-03-01
• First posted: 2015-05-05
• Last updated: 2019-10-24

Locations

5 sites across 1 country: France